Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
---- 7.11 7.11 13.75 7.11 7.11
---+ 7.11 7.11 13.75 7.11 7.11
--+- 7.11 7.11 13.75 7.11 7.11
--++ 7.11 7.11 13.75 7.11 7.11
-+-- 7.11 7.11 13.75 7.11 7.11
-+-+ 7.11 7.11 13.75 7.11 7.11
-++- 7.11 7.11 13.75 7.11 7.11
-+++ 7.11 7.11 13.75 7.11 7.11
+--- 7.11 7.11 13.75 7.11 7.11
+--+ 7.11 7.11 13.75 7.11 7.11
+-+- 7.11 7.11 13.75 7.11 7.11
+-++ 7.11 7.11 13.75 7.11 7.11
++-- 7.11 7.11 13.75 7.11 7.11
++-+ 7.11 7.11 13.75 7.11 7.11
+++- 7.11 7.11 13.75 7.11 7.11
$superiority
Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
all 0 0 1 0 0
TP53- & AR- 0 0 0 0 0
TP53+ 0 0 1 0 0
DRD+ 0 0 0 0 0
TEfus+ 0 0 0 0 0
$inferiority
Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
all 0 0 0 0 0
TP53- & AR- 0 0 0 0 0
TP53+ 0 0 0 0 0
DRD+ 0 0 0 0 0
TEfus+ 0 0 0 0 0
$p_sign
Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
all 0.65 0.66 0.99 0.53 0.75
TP53- & AR- 0.41 0.46 1.00 0.87 0.69
TP53+ 0.84 0.71 0.94 0.61 0.57
DRD+ 0.55 0.72 0.85 0.72 0.69
TEfus+ 0.64 0.31 0.91 0.57 0.74
$p_type
Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
---- 0.21 0.31 1.00 0.15 0.45
---+ 0.73 0.65 0.93 0.80 0.84
--+- 0.97 0.60 0.93 0.24 0.52
--++ 0.51 0.62 0.97 0.74 0.53
-+-- 0.33 0.34 0.84 0.68 0.45
-+-+ 0.46 0.50 0.66 0.87 0.53
-++- 0.48 0.74 0.64 0.54 0.35
-+++ 0.68 0.53 0.55 0.50 0.51
+--- 0.49 0.71 0.65 0.26 0.46
+--+ 0.34 0.09 0.38 0.17 0.54
+-+- 0.53 0.61 0.60 0.55 0.52
+-++ 0.57 0.25 0.64 0.31 0.54
++-- 0.30 0.70 0.79 0.32 0.71
++-+ 0.47 0.45 0.47 0.40 0.64
+++- 0.73 0.70 0.60 0.76 0.66
Control Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
---- 153 28 59 27 43 43
---+ 19 14 15 4 16 10
--+- 54 54 29 16 12 18
--++ 38 12 19 6 25 15
-+-- 37 1 2 8 8 5
-+-+ 17 4 3 9 12 7
-++- 4 2 6 2 3 3
-+++ 4 3 0 0 1 3
+--- 19 8 15 2 2 7
+--+ 11 7 5 1 5 16
+-+- 3 2 4 0 1 1
+-++ 19 4 5 3 7 10
++-- 5 6 6 2 6 5
++-+ 1 1 0 2 2 3
+++- 5 1 1 1 2 1
Control Enzalutamide Abiraterone Carboplatin Cabazitaxel Docetaxel
all 389 147 169 83 145 147
TP53- & AR- 226 47 79 48 79 65
TP53+ 127 78 64 28 51 51
DRD+ 73 18 18 24 34 27
TEfus+ 109 45 47 25 68 64
Sample of 10 rows:
id trt trt2 line subtype delta month0 time_m all TP53- & AR- TP53+ DRD+ TEfus+
565 507 Cabazitaxel Cabazitaxel 1 +-++ 1 16 1.1326152 1 0 1 0 1
264 244 Control Docetaxel 1 --+- 1 8 4.6989086 1 0 1 0 0
158 150 Docetaxel Docetaxel 1 +--+ 1 4 12.2078841 1 0 0 0 1
120 113 Carboplatin Carboplatin 1 +++- 1 3 1.6844444 1 0 1 1 0
1005 902 Control Enzalutamide 1 ---- 1 30 0.9303245 1 1 0 0 0
261 241 Control Enzalutamide 1 ---- 1 8 23.1234898 1 1 0 0 0
1006 903 Control Enzalutamide 1 ---- 1 30 2.2252601 1 1 0 0 0
262 242 Control Abiraterone 1 ---- 1 8 5.5241276 1 1 0 0 0
956 866 Cabazitaxel Cabazitaxel 1 -+-+ 1 28 1.0317802 1 1 0 1 1
131 123 Control Abiraterone 1 --+- 1 4 6.9556186 1 0 1 0 0
Mean number of progressions and follow-up time:
$all
# A tibble: 6 x 4
trt progressions PT rate
<fct> <dbl> <dbl> <dbl>
1 Control 334 2387. 0.140
2 Enzalutamide 143 1097. 0.130
3 Abiraterone 147 1038. 0.142
4 Carboplatin 78 1030. 0.0757
5 Cabazitaxel 144 962. 0.150
6 Docetaxel 122 922. 0.132
$`TP53- & AR-`
# A tibble: 6 x 4
trt progressions PT rate
<fct> <dbl> <dbl> <dbl>
1 Control 197 1454. 0.136
2 Enzalutamide 54 347. 0.156
3 Abiraterone 74 503. 0.147
4 Carboplatin 44 626. 0.0703
5 Cabazitaxel 76 585. 0.130
6 Docetaxel 51 398. 0.128
$`TP53+`
# A tibble: 6 x 4
trt progressions PT rate
<fct> <dbl> <dbl> <dbl>
1 Control 108 702. 0.154
2 Enzalutamide 65 595. 0.109
3 Abiraterone 54 381. 0.142
4 Carboplatin 27 319. 0.0846
5 Cabazitaxel 50 312. 0.160
6 Docetaxel 50 315. 0.159
$`DRD+`
# A tibble: 6 x 4
trt progressions PT rate
<fct> <dbl> <dbl> <dbl>
1 Control 65 470. 0.138
2 Enzalutamide 18 112. 0.161
3 Abiraterone 10 105. 0.0950
4 Carboplatin 24 269. 0.0893
5 Cabazitaxel 26 236. 0.110
6 Docetaxel 22 181. 0.122
$`TEfus+`
# A tibble: 6 x 4
trt progressions PT rate
<fct> <dbl> <dbl> <dbl>
1 Control 89 599. 0.148
2 Enzalutamide 48 348. 0.138
3 Abiraterone 45 254. 0.177
4 Carboplatin 25 297. 0.0843
5 Cabazitaxel 64 478. 0.134
6 Docetaxel 51 416. 0.123
Kaplan-Meier results:
$all
Call: survfit(formula = Surv(time_m, delta) ~ trt, data = d)
n events median 0.95LCL 0.95UCL
trt=Control 439 334 4.76 4.35 5.73
trt=Enzalutamide 166 143 5.90 5.17 7.19
trt=Abiraterone 181 147 5.33 4.43 6.37
trt=Carboplatin 89 78 9.00 6.19 13.45
trt=Cabazitaxel 164 144 4.74 3.88 5.73
trt=Docetaxel 158 122 5.18 4.56 6.54
$`TP53- & AR-`
Call: survfit(formula = Surv(time_m, delta) ~ trt, data = d)
n events median 0.95LCL 0.95UCL
trt=Control 253 197 4.83 4.19 6.55
trt=Enzalutamide 58 54 5.78 3.66 7.94
trt=Abiraterone 85 74 5.26 3.83 6.58
trt=Carboplatin 52 44 10.12 5.65 16.18
trt=Cabazitaxel 91 76 5.73 5.20 7.01
trt=Docetaxel 70 51 4.70 3.88 6.93
$`TP53+`
Call: survfit(formula = Surv(time_m, delta) ~ trt, data = d)
n events median 0.95LCL 0.95UCL
trt=Control 144 108 4.42 3.63 5.55
trt=Enzalutamide 83 65 6.86 5.19 9.23
trt=Abiraterone 68 54 5.23 3.86 7.35
trt=Carboplatin 29 27 9.00 6.23 17.01
trt=Cabazitaxel 55 50 4.28 3.17 6.18
trt=Docetaxel 55 50 5.26 3.61 6.85
$`DRD+`
Call: survfit(formula = Surv(time_m, delta) ~ trt, data = d)
n events median 0.95LCL 0.95UCL
trt=Control 79 65 5.03 3.27 7.00
trt=Enzalutamide 19 18 4.16 2.22 12.39
trt=Abiraterone 19 10 4.96 4.20 NA
trt=Carboplatin 25 24 6.71 5.63 15.06
trt=Cabazitaxel 36 26 6.74 3.88 13.33
trt=Docetaxel 30 22 6.54 3.88 9.26
$`TEfus+`
Call: survfit(formula = Surv(time_m, delta) ~ trt, data = d)
n events median 0.95LCL 0.95UCL
trt=Control 119 89 4.95 3.65 6.41
trt=Enzalutamide 53 48 5.46 4.82 9.40
trt=Abiraterone 51 45 3.48 2.60 5.54
trt=Carboplatin 28 25 7.04 5.49 17.01
trt=Cabazitaxel 77 64 5.18 3.88 6.33
trt=Docetaxel 68 51 5.26 4.56 8.30